Vote for your favorite mineral in #MinCup25! - Dioptase vs. Wavellite
It's a green, green world for kiwi #wavellite vs desert emerald #dioptase.
Log InRegister
Quick Links : The Mindat ManualThe Rock H. Currier Digital LibraryMindat Newsletter [Free Download]
Home PageAbout MindatThe Mindat ManualHistory of MindatCopyright StatusWho We AreContact UsAdvertise on Mindat
Donate to MindatCorporate SponsorshipSponsor a PageSponsored PagesMindat AdvertisersAdvertise on Mindat
Learning CenterWhat is a mineral?The most common minerals on earthInformation for EducatorsMindat ArticlesThe ElementsThe Rock H. Currier Digital LibraryGeologic Time
Minerals by PropertiesMinerals by ChemistryAdvanced Locality SearchRandom MineralRandom LocalitySearch by minIDLocalities Near MeSearch ArticlesSearch GlossaryMore Search Options
Search For:
Mineral Name:
Locality Name:
Keyword(s):
 
The Mindat ManualAdd a New PhotoRate PhotosLocality Edit ReportCoordinate Completion ReportAdd Glossary Item
Mining CompaniesStatisticsUsersMineral MuseumsClubs & OrganizationsMineral Shows & EventsThe Mindat DirectoryDevice SettingsThe Mineral Quiz
Photo SearchPhoto GalleriesSearch by ColorNew Photos TodayNew Photos YesterdayMembers' Photo GalleriesPast Photo of the Day GalleryPhotography

Remsing, Lily L., González, Ana M., Nur-e-Alam, Mohammad, Fernández-Lozano, M. José, Braña, Alfredo F., Rix, Uwe, Oliveira, Marcos A., Méndez, Carmen, Salas, José A., Rohr, Jürgen (2003) Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK:  Three New Products Generated in the Mithramycin ProducerStreptomycesargillaceusthrough Combinatorial Biosynthesis. Journal Of The American Chemical Society, 125 (19) 5745-5753 doi:10.1021/ja034162h

Advanced
   -   Only viewable:
Reference TypeJournal (article/letter/editorial)
TitleMithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK:  Three New Products Generated in the Mithramycin ProducerStreptomycesargillaceusthrough Combinatorial Biosynthesis
JournalJournal Of The American Chemical Society
AuthorsRemsing, Lily L.Author
González, Ana M.Author
Nur-e-Alam, MohammadAuthor
Fernández-Lozano, M. JoséAuthor
Braña, Alfredo F.Author
Rix, UweAuthor
Oliveira, Marcos A.Author
Méndez, CarmenAuthor
Salas, José A.Author
Rohr, JürgenAuthor
Year2003 (May)Volume125
Issue19
PublisherAmerican Chemical Society (ACS)
DOIdoi:10.1021/ja034162hSearch in ResearchGate
Generate Citation Formats
Mindat Ref. ID1607714Long-form Identifiermindat:1:5:1607714:0
GUID0
Full ReferenceRemsing, Lily L., González, Ana M., Nur-e-Alam, Mohammad, Fernández-Lozano, M. José, Braña, Alfredo F., Rix, Uwe, Oliveira, Marcos A., Méndez, Carmen, Salas, José A., Rohr, Jürgen (2003) Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK:  Three New Products Generated in the Mithramycin ProducerStreptomycesargillaceusthrough Combinatorial Biosynthesis. Journal Of The American Chemical Society, 125 (19) 5745-5753 doi:10.1021/ja034162h
Plain TextRemsing, Lily L., González, Ana M., Nur-e-Alam, Mohammad, Fernández-Lozano, M. José, Braña, Alfredo F., Rix, Uwe, Oliveira, Marcos A., Méndez, Carmen, Salas, José A., Rohr, Jürgen (2003) Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK:  Three New Products Generated in the Mithramycin ProducerStreptomycesargillaceusthrough Combinatorial Biosynthesis. Journal Of The American Chemical Society, 125 (19) 5745-5753 doi:10.1021/ja034162h
In(2003, May) Journal Of The American Chemical Society Vol. 125 (19) American Chemical Society (ACS)

See Also

These are possibly similar items as determined by title/reference text matching only.

Remsing, Lily L., Garcia-Bernardo, Jose, Gonzalez, Ana, Künzel, Eva, Rix, Uwe, Braña, Alfredo F., Bearden, Daniel W., Méndez, Carmen, Salas, Jose A., Rohr, Jürgen (2002) Ketopremithramycins and Ketomithramycins, Four New Aureolic Acid-Type Compounds Obtained upon Inactivation of Two Genes Involved in the Biosynthesis of the Deoxysugar Moieties of the Antitumor Drug Mithramycin byStreptomycesArgillaceus, Reveal Novel Insights into Post-PKS Tailoring Steps of the Mithramycin Biosynthetic Pathway. Journal Of The American Chemical Society, 124 (8) 1606-1614 doi:10.1021/ja0105156
Baig, Irfan, Perez, María, Braña, Alfredo F., Gomathinayagam, Rohini, Damodaran, Chendil, Salas, Jose A., Méndez, Carmen, Rohr, Jürgen (2008) Mithramycin Analogues Generated by Combinatorial Biosynthesis Show Improved Bioactivity. Journal of Natural Products, 71. 199-207 doi:10.1021/np0705763
Flórez, Ana B., Álvarez, Susana, Zabala, Daniel, Braña, Alfredo F., Salas, José A., Méndez, Carmen (2015) Transcriptional regulation of mithramycin biosynthesis in Streptomyces argillaceus: dual role as activator and repressor of the PadR-like regulator MtrY. Microbiology, 161. 272-284 doi:10.1099/mic.0.080895-0
Lombó, Felipe, Künzel, Eva, Prado, Laura, Braña, Alfredo F., Bindseil, Kai U., Frevert, Jürgen, Bearden, Dan, Méndez, Carmen, Salas, José A., Rohr, Jürgen (2000) The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin. Angewandte Chemie International Edition, 39 (4). 796-799 doi:10.1002/(sici)1521-3773(20000218)39:4<796::aid-anie796>3.0.co;2-n
Gibson, Miranda, Nur-e-alam, Mohammad, Lipata, Fredilyn, Oliveira, Marcos A., Rohr, Jürgen (2005) Characterization of Kinetics and Products of the Baeyer−Villiger Oxygenase MtmOIV, The Key Enzyme of the Biosynthetic Pathway toward the Natural Product Anticancer Drug Mithramycin fromStreptomycesargillaceus. Journal Of The American Chemical Society, 127 (50) 17594-17595 doi:10.1021/ja055750t
Trefzer, Axel, Blanco, Gloria, Remsing, Lily, Künzel, Eva, Rix, Uwe, Lipata, Fredilyn, Braña, Alfredo F., Méndez, Carmen, Rohr, Jürgen, Bechthold, Andreas, Salas, José A. (2002) Rationally Designed Glycosylated Premithramycins:  Hybrid Aromatic Polyketides Using Genes from Three Different Biosynthetic Pathways. Journal Of The American Chemical Society, 124 (21) 6056-6062 doi:10.1021/ja017385l
Lombó, Felipe, Künzel, Eva, Prado, Laura, Braña, Alfredo F., Bindseil, Kai U., Frevert, Jürgen, Bearden, Dan, Méndez, Carmen, Salas, José A., Rohr, Jürgen (2000) Die antitumorwirksame Hybrid-Verbindung Premithramycinon H verweist indirekt auf ein tricyclisches Intermediat der Biosynthese des Aureolsäure-Antibiotikums Mithramycin. Angewandte Chemie, 112 (4). 808-811 doi:10.1002/(sici)1521-3757(20000218)112:4<808::aid-ange808>3.0.co;2-3
Wohlert, S. E., Künzel, E., Machinek, R., Méndez, C., Salas, J. A., Rohr, J. (1999) The Structure of Mithramycin Reinvestigated. Journal of Natural Products, 62. 119-121 doi:10.1021/np980355k
Künzel, Eva, Wohlert, Sven-Eric, Beninga, Claus, Haag, Sabine, Decker, Heinrich, Hutchinson, C. Richard, Blanco, Gloria, Mendez, Carmen, Salas, Jose A., Rohr, Jürgen (1997) Tetracenomycin M, a Novel Genetically Engineered Tetracenomycin Resulting from a Combination of Mithramycin and Tetracenomycin Biosynthetic Genes. Chemistry - A European Journal, 3 (10). 1675-1678 doi:10.1002/chem.19970031017
Ramos, Angelina, Lombó, Felipe, Braña, Alfredo F., Rohr, Jürgen, Méndez, Carmen, Salas, José A. (2008) Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster. Microbiology, 154. 781-788 doi:10.1099/mic.0.2007/014035-0
Rix, Uwe, Zheng, Jianting, Remsing Rix, Lily L., Greenwell, Lisa, Yang, Keqian, Rohr, Jürgen (2004) The Dynamic Structure of Jadomycin B and the Amino Acid Incorporation Step of Its Biosynthesis. Journal Of The American Chemical Society, 126 (14) 4496-4497 doi:10.1021/ja031724o
 
and/or  
Mindat.org is an outreach project of the Hudson Institute of Mineralogy, a 501(c)(3) not-for-profit organization.
Copyright © mindat.org and the Hudson Institute of Mineralogy 1993-2025, except where stated. Most political location boundaries are © OpenStreetMap contributors. Mindat.org relies on the contributions of thousands of members and supporters. Founded in 2000 by Jolyon Ralph.
To cite: Ralph, J., Von Bargen, D., Martynov, P., Zhang, J., Que, X., Prabhu, A., Morrison, S. M., Li, W., Chen, W., & Ma, X. (2025). Mindat.org: The open access mineralogy database to accelerate data-intensive geoscience research. American Mineralogist, 110(6), 833–844. doi:10.2138/am-2024-9486.
Privacy Policy - Terms & Conditions - Contact Us / DMCA issues - Report a bug/vulnerability Current server date and time: September 10, 2025 21:33:32
Go to top of page